LTBR antibody

GeneTex

LTBR antibody

10

Flow Cytometry, Western Blot

Research Use Only

Polyclonal

Goat

IgG

Tumor necrosis factor-beta (TNF-beta), also known as lymphotoxin (LT or LT-a) and cytotoxic factor, is a 25 kDa glycoprotein that is tightly regulated by lymphocytes. TNF-beta and TNF-alpha share a 28% amino acid sequence identity, and as soluble forms, both can exist in solution as homotrimers, activate the same TNF receptors (TNFR1 and TNFR2) and elicit many of the same bioactivities. Unlike TNF-alpha, TNF-beta can also form heterotrimers with one or two molecules of the related membrane-bound lymphotoxin-beta (LT-beta). Reportedly, LT-alpha1/beta2, the predominant heterotrimer, binds and activates only the LT-beta receptor, LT-betaR. The other heterotrimer, LT-alpha2/beta1 binds and activates TNFR1 and TNFR2 but not LT-betaR. TNF-beta is expressed in activated T, B and NK cells and in certain transformed cells. Genes for TNF-beta, LT-beta and TNF-alpha are tightly linked near each other within the MHC. TNF-beta appears to play many of the same biological roles as TNF-alpha, but the membrane-bound form with LT-beta is critical for normal lymphoid organ development. Genetic polymorphisms in TNF-alpha and TNF-beta have been linked to certain pathological conditions, including myasthenia gravis. At the amino acid level, human and mouse TNF-beta are 74% homologous and human and mouse LT-beta are 80% homologous.

Human

2°C to 8°C,-20°C

12352203