GTX106211 WB Image
GTX106211 WB Image
MADH7 antibody
GTX106211
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameMADH7 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Characterization of TGF-beta by Induced Oxidative Stress in Human Trabecular Meshwork Cells. Chen HY et al., 2021 Jan 13, Antioxidants (Basel)Read more
- Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFbeta receptor degradation. Hsu HY et al., 2014 Sep 15, OncotargetRead more
- Fucose-containing fraction of Ling-Zhi enhances lipid rafts-dependent ubiquitination of TGFbeta receptor degradation and attenuates breast cancer tumorigenesis. Tsao SM et al., 2016 Nov 10, Sci RepRead more