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MAPK1/3 antibody, PAb

Research Use Only
ORB18046
Biorbyt
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityChicken, Human, Mouse, Rat
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Biorbyt
  • Product Name
    MAPK1/3 antibody, PAb
  • Delivery Days Customer
    10
  • Applications
    Western Blot, ImmunoHistoChemistry
  • Applications Supplier
    Western blot - 0.1-0.5 μg/ml - Human - Mouse, Rat - Immunohistochemistry(Paraffin-embedded Section) - 0.5-1 μg/ml - Human - Mouse, Rat - By Heat WB, IHC
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    500 ug/ml
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Rabbit Polyclonal to MAPK1/3. MAPK1(ERK2) shares high homology with MAPK3(ERK1). MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Mitogen-activated protein (MAP) kinases [also known as Erks] have been established to function as important mediators of signal transduction by growth factor receptors. ERK1/ERK2-dependent activation of endogenous ribosomal transcription, while inactivation of ERK1/ERK2 causes an equally immediate reversion to the basal transcription level. ERK1/ERK2 was found to phosphorylate the architectural transcription factor UBF at amino acids 117 and 201 within HMG boxes 1 and 2, preventing their interaction with DNA. Mutation of these sites inhibited transcription activation and abrogated the transcriptional response to ERK1/ERK2.
  • Reactivity
    Chicken, Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203