MAPKBP1 antibody

Biorbyt

MAPKBP1 antibody

16

WB: 1:200-500, IHC-P: 1:50-100 IHC-P, WB

Research Use Only

IgG

Rabbit polyclonal antibody to MAPKBP1. MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. MAPKBP1 (mitogenactivated protein kinase binding protein 1), also known as JNKBP1, is a 1,514 amino acid protein that contains twelve WD repeats. Induced by TRAF2 (TNF receptorassociated factor 2) and Tak1 (TGF beta activated kinase 1), MAPKBP1 is thought to act an adaptor protein for NFkB (nuclear factor kB) activation. MAPKBP1 interacts with JNK3 and may promote TRAF2 polyubiquitination. MAPKBP1 exists as six alternatively spliced variants and is encoded by a gene located on human chromosome 15. Human chromosome 15 houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, PraderWilli syndrome, TaySachs disease and Marfan syndrome are all associated with defects in chromosome 15localized genes.

-20°C

12352203