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GTX108190 IHC-P Image
GTX108190 IHC-P Image
GTX108190 IHC-P Image

MC1 Receptor antibody [C2C3], C-term

Research Use Only
GTX108190
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    MC1 Receptor antibody [C2C3], C-term
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1.39 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Heterobivalent ligands target cell-surface receptor combinations in vivo. Xu L et al., 2012 Dec 26, Proc Natl Acad Sci U S A
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  • NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-kappaB pathway after intracerebral hemorrhage in mice. Wu X et al., 2019 Oct 28, J Neuroinflammation
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  • The anti-melanogenic effects of 3-O-ethyl ascorbic acid via Nrf2-mediated alpha-MSH inhibition in UVA-irradiated keratinocytes and autophagy induction in melanocytes. Chen SJ et al., 2021 Sep, Free Radic Biol Med
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  • The in vitro and in vivo depigmenting activity of pterostilbene through induction of autophagy in melanocytes and inhibition of UVA-irradiated alpha-MSH in keratinocytes via Nrf2-mediated antioxidant pathways. Hseu YC et al., 2021 Aug, Redox Biol
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