GTX104658 IHC-P Image
GTX104658 IHC-P Image
MMP7 antibody [C2C3], C-term
GTX104658
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameMMP7 antibody [C2C3], C-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.48 mg/ml
- IsotypeIgG
- Scientific DescriptionProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- C-X-C Chemokine Receptor Type 4 Plays a Crucial Role in Mediating Oxidative Stress-Induced Podocyte Injury. Mo H et al., 2017 Aug 20, Antioxid Redox SignalRead more
- Early activation of fibroblasts is required for kidney repair and regeneration after injury. Zhou D et al., 2019 Nov, FASEB JRead more
- FHL2 promotes tubular epithelial-to-mesenchymal transition through modulating beta-catenin signalling. Cai T et al., 2018 Mar, J Cell Mol MedRead more
- Inhibition of cancer cell migration and invasion through suppressing the Wnt1-mediating signal pathway by G-quadruplex structure stabilizers. Wang JM et al., 2014 May 23, J Biol ChemRead more
- Inhibition of matrix metalloproteinase activity reverses corneal endothelial-mesenchymal transition. Ho WT et al., 2015 Aug, Am J PatholRead more
- Kidney tubular beta-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication. Zhou D et al., 2013, Sci RepRead more
- Klotho Ameliorates Kidney Injury and Fibrosis and Normalizes Blood Pressure by Targeting the Renin-Angiotensin System. Zhou L et al., 2015 Dec, Am J PatholRead more
- MMP7 cleaves remyelination-impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions. Wang P et al., 2018 Aug, GliaRead more
- Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney. Oelusarz A et al., 2013 Oct, Physiol RepRead more
- The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma. Luo W et al., 2018 Feb 21, World J Surg OncolRead more