GTX70212 WB Image
GTX70212 WB Image
Mre11 antibody [12D7] - KO/KD, Comparison Validated
GTX70212
ApplicationsFunctional Assay, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
ReactivityHuman, Mouse, Rat
Overview
- SupplierGeneTex
- Product NameMre11 antibody [12D7] - KO/KD, Comparison Validated
- Delivery Days Customer10
- ApplicationsFunctional Assay, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID12D7
- Concentration0.45 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionThis gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3 to 5 exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3 to 5 exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- 3D culture conditions support Kaposis sarcoma herpesvirus (KSHV) maintenance and viral spread in endothelial cells. Dubich T et al., 2021 Mar, J Mol Med (Berl)Read more
- A glycine-arginine domain in control of the human MRE11 DNA repair protein. Dery U et al., 2008 May, Mol Cell BiolRead more
- A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Stewart R et al., 2013 Jun 15, Hum Mol GenetRead more
- A requirement for polymerized actin in DNA double-strand break repair. Andrin C et al., 2012 Jul 1, NucleusRead more
- Activation of DNA Damage Response Pathways during Lytic Replication of KSHV. Hollingworth R et al., 2015 Jun 5, VirusesRead more
- Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage. Jian W et al., 2014 Sep, Anticancer DrugsRead more
- Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways. Collaco RF et al., 2009 Sep 15, VirologyRead more
- Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase. Schwartz RA et al., 2009 Jun, J VirolRead more
- Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes. Fleisig HB et al., 2007 Jul 19, OncogeneRead more
- Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection. Karen KA et al., 2011 May, J VirolRead more