GTX118741 IP Image
GTX118741 IP Image
Mre11 antibody
GTX118741
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameMre11 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.57 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3 to 5 exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3 to 5 exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Degradation of a Novel DNA Damage Response Protein, Tankyrase 1 Binding Protein 1, following Adenovirus Infection. Chalabi Hagkarim N et al., 2018 Jun 15, J VirolRead more
- Inhibition of non-homologous end joining in Fanconi Anemia cells results in rescue of survival after interstrand crosslinks but sensitization to replication associated double-strand breaks. Eccles LJ et al., 2018 Apr, DNA Repair (Amst)Read more
- PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression. Honda T et al., 2020 Jan 24, Sci RepRead more
- The E1B19K-deleted oncolytic adenovirus mutant Addelta19K sensitizes pancreatic cancer cells to drug-induced DNA-damage by down-regulating Claspin and Mre11. Pantelidou C et al., 2016 Mar 29, OncotargetRead more
- Timely synthesis of the adenovirus type 5 E1B 55-kilodalton protein is required for efficient genome replication in normal human cells. Chahal JS et al., 2012 Mar, J VirolRead more
- YM155 and BIRC5 downregulation induce genomic instability via autophagy-mediated ROS production and inhibition in DNA repair. Cheng SM et al., 2021 Apr, Pharmacol ResRead more