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GTX116046 IHC-P Image
GTX116046 IHC-P Image
GTX116046 IHC-P Image

MRP1 antibody [N1N2], N-term

Research Use Only
GTX116046
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    MRP1 antibody [N1N2], N-term
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1.73 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

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  • Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells. Maruhashi R et al., 2019 Sep 24, Sci Rep
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  • Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models. Maruhashi R et al., 2018 Mar, Biochim Biophys Acta Mol Cell Res
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  • Increase in resistance to anticancer drugs involves occludin in spheroid culture model of lung adenocarcinoma A549 cells. Eguchi H et al., 2018 Oct 11, Sci Rep
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  • Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. Liang X et al., 2017 Mar 28, Br J Cancer
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  • MEK inhibitor enhances sensitivity to chemotherapeutic drugs in multidrug resistant hepatocellular carcinoma cells. Meng Q et al., 2017 Sep, Oncol Lett
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  • Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. Lin GL et al., 2017, PLoS One
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  • Paeonol reverses paclitaxel resistance in human breast cancer cells by regulating the expression of transgelin 2. Cai J et al., 2014 Jun 15, Phytomedicine
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  • Proteomic analysis of the proteins that are associated with the resistance to paclitaxel in human breast cancer cells. Chen S et al., 2014 Feb, Mol Biosyst
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  • Transgelin 2 Promotes Paclitaxel Resistance, Migration, and Invasion of Breast Cancer by Directly Interacting with PTEN and Activating PI3K/Akt/GSK-3beta Pathway. Liu L et al., 2019 Dec, Mol Cancer Ther
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