GTX107678 WB Image
GTX107678 WB Image
NFkB p65 antibody
GTX107678
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameNFkB p65 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.46 mg/ml
- IsotypeIgG
- Scientific DescriptionNFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- 2,3,5,4-Tetrahydroxystilbene-2-O-beta-glucoside Isolated from Polygoni Multiflori Ameliorates the Development of Periodontitis. Chin YT et al., 2016, Mediators InflammRead more
- A high-throughput pipeline for validation of antibodies. Sikorski K et al., 2018 Nov, Nat MethodsRead more
- Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model. Schiaffino L et al., 2018 Aug 27, Sci RepRead more
- Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Adrianto I et al., 2011 Mar, Nat GenetRead more
- Effects of intrauterine growth retardation and postnatal high-fat diet on hepatic inflammatory response in pigs. Liu J et al., 2014, Arch Anim NutrRead more
- Functional module analysis reveals differential osteogenic and stemness potentials in human mesenchymal stem cells from bone marrow and Whartons jelly of umbilical cord. Hsieh JY et al., 2010 Dec, Stem Cells DevRead more
- Ganoderma lucidum Polysaccharides Reduce Lipopolysaccharide-Induced Interleukin-1 beta Expression in Cultured Smooth Muscle Cells and in Thoracic Aortas in Mice. Liang CJ et al., 2014, Evid Based Complement Alternat MedRead more
- Huoxin Pill Attenuates Cardiac Inflammation by Suppression of TLR4/NF-kappaB in Acute Myocardial Ischemia Injury Rats. Chu J et al., 2020, Evid Based Complement Alternat MedRead more
- Increased serum HMGB1 levels in patients with Henoch-Schoenlein purpura. Chen T et al., 2014 Jun, Exp DermatolRead more
- Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma. Raninga PV et al., 2015 Jun 20, OncotargetRead more