GTX27970 IHC-P Image
NFkB p65 antibody
GTX27970
ApplicationsGel Shift Assay, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
Overview
- SupplierGeneTex
- Product NameNFkB p65 antibody
- Delivery Days Customer10
- ApplicationsGel Shift Assay, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.2 mg/ml
- HostRabbit
- IsotypeIgG
- Scientific DescriptionNF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
- ReactivityHuman, Mouse, Rat
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Nuclear BCL-10 expression is common in lymphoplasmacytic lymphoma/Waldenstroem macroglobulinemia and does not correlate with p65 NF-kappaB activation. Merzianu M et al., 2006 Jul, Mod PatholRead more
- Sustained inflammation due to nuclear factor-kappa B activation in irradiated human arteries. Halle M et al., 2010 Mar 23, J Am Coll CardiolRead more
- Systemic inflammation activates the nuclear factor-kappaB regulatory pathway in adipose tissue. Ekstroem M et al., 2010 Aug, Am J Physiol Endocrinol MetabRead more