GTX41968 WB Image
NKCC2 antibody
GTX41968
Overview
- SupplierGeneTex
- Product NameNKCC2 antibody
- Delivery Days Customer10
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- HostRabbit
- IsotypeIgG
- Scientific DescriptionNKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell. Transport of sodium dilutes the luminal fluid, decreasing its osmolality creating an osmotic driving force for water reabsorption in the connecting tubule and cortical collecting duct under the influence of the hormone vasopressin. NKCC2 is found on the apical surface of the thick ascending limb of the loop of Henle and is blocked by loop diuretics such as furosemide.
- ReactivityHuman, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. Toka HR et al., 2012 Nov, J Am Soc NephrolRead more
- Exacerbation of celecoxib-induced renal injury by concomitant administration of misoprostol in rats. Cooper DL et al., 2014, PLoS OneRead more