Notch1 antibody, MAb (Biotin)
ORB150337
ApplicationsWestern Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
Overview
- SupplierBiorbyt
- Product NameNotch1 antibody, MAb (Biotin)
- Delivery Days Customer10
- ApplicationsWestern Blot, ImmunoCytoChemistry
- Applications SupplierWB (1:1000) ICC, WB
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDS253-32
- Concentration1 mg/ml
- ConjugateBiotin
- HostMouse
- IsotypeIgG1
- Scientific DescriptionMouse monoclonal to Notch1 (Biotin). Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane..
- ReactivityHuman, Mouse, Rat
- Storage Instruction2°C to 8°C
- UNSPSC12352203