Notch1 antibody, MAb (Biotin)

Biorbyt

Notch1 antibody, MAb (Biotin)

10

Western Blot, ImmunoCytoChemistry

WB (1:1000) ICC, WB

Research Use Only

Monoclonal

S253-32

1 mg/ml

Biotin

Mouse

IgG1

Mouse monoclonal to Notch1 (Biotin). Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane..

Human, Mouse, Rat

2°C to 8°C

12352203