GTX121929 WB Image
GTX121929 WB Image
NOX4 antibody [N3C3]
GTX121929
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameNOX4 antibody [N3C3]
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.84 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Effect of (-)-epicatechin on the modulation of progression markers of chronic renal damage in a 5/6 nephrectomy experimental model. Montes-Rivera J et al., 2019 Apr, HeliyonRead more
- Gallbladder cancer-associated fibroblasts promote vasculogenic mimicry formation and tumor growth in gallbladder cancer via upregulating the expression of NOX4, a poor prognosis factor, through IL-6-JAK-STAT3 signal pathway. Pan MS et al., 2020 Nov 5, J Exp Clin Cancer ResRead more
- Gallic Acid Reduces Blood Pressure and Attenuates Oxidative Stress and Cardiac Hypertrophy in Spontaneously Hypertensive Rats. Jin L et al., 2017 Nov 15, Sci RepRead more
- Kidney dysfunction in the low-birth weight murine adult: implications of oxidative stress. Abdulmahdi W et al., 2018 Sep 1, Am J Physiol Renal PhysiolRead more
- MicroRNA-146a decreases high glucose/thrombin-induced endothelial inflammation by inhibiting NAPDH oxidase 4 expression. Wang HJ et al., 2014, Mediators InflammRead more
- Muscone relieves inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4/JAK2-STAT3 pathway and NLRP3 inflammasome. Yu S et al., 2020 Mar 4, Int ImmunopharmacolRead more
- Neuronal NAD(P)H oxidases contribute to ROS production and mediate RGC death after ischemia. Dvoriantchikova G et al., 2012 May 14, Invest Ophthalmol Vis SciRead more
- NOX4 overexpression is a poor prognostic factor in patients undergoing curative esophagectomy for esophageal squamous cell carcinoma. Chen YH et al., 2020 Mar, SurgeryRead more
- Protective effects of valsartan administration on doxorubicin-induced myocardial injury in rats and the role of oxidative stress and NOX2/NOX4 signaling. Cheng D et al., 2020 Nov, Mol Med RepRead more
- Protective effects of valsartan administration on doxorubicin-induced myocardial injury in rats and the role of oxidative stress and NOX2/NOX4 signaling. Cheng D et al., 2020 Nov, Mol Med RepRead more