NSE Antibody / Neuron Specific Enolase

Biorbyt

NSE Antibody / Neuron Specific Enolase

16

ImmunoHistoChemistry

Immunohistochemistry (FFPE): 0.1-0.2ug/ml for 30 min at RT IHC-P

Research Use Only

SPM347

IgG

Recognizes a protein of about 50kDa, which is identified as gamma-Enolase/Neuron Specific Enolase/Enolase 2. Three isoenzymes of enolases are identified, alpha, beta and gamma. Alpha-isoform is expressed in most tissues, whereas beta-form is expressed predominantly in muscle tissue and gamma-enolase is found only in nervous tissue. These isoforms exist as both homodimers and heterodimers, and they play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in the glycolytic pathway. NSE is a useful marker to identify peripheral nerves and tumors of neuro-endocrine origins, such as pheochromocytomas. It it be usually employed in combination with other markers such as Synaptophysin, Chromogranin A, and Neurofilament.

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