GTX108354 WB Image
GTX108354 WB Image
P Glycoprotein antibody
GTX108354
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameP Glycoprotein antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.07 mg/ml
- IsotypeIgG
- Scientific DescriptionThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. Kim DG et al., 2016 May 2, J Clin InvestRead more
- CD73 Promotes Glioblastoma Pathogenesis and Enhances Its Chemoresistance via A2B Adenosine Receptor Signaling. Yan A et al., 2019 May 29, J NeurosciRead more
- Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells. Maruhashi R et al., 2019 Sep 24, Sci RepRead more
- Increase in resistance to anticancer drugs involves occludin in spheroid culture model of lung adenocarcinoma A549 cells. Eguchi H et al., 2018 Oct 11, Sci RepRead more
- MEK inhibitor enhances sensitivity to chemotherapeutic drugs in multidrug resistant hepatocellular carcinoma cells. Meng Q et al., 2017 Sep, Oncol LettRead more
- Upregulation of Chemoresistance by Mg2+ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells. Onuma S et al., 2021 May 12, CellsRead more