GTX17353 WB Image
p27 Kip1 (phospho Ser10) antibody
GTX17353
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
Overview
- SupplierGeneTex
- Product Namep27 Kip1 (phospho Ser10) antibody
- Delivery Days Customer10
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- HostRabbit
- IsotypeIgG
- Modification TypePhosphorylated
- Scientific DescriptionThis gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells. So EC et al., 2016, Onco Targets TherRead more