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GTX102425 IP Image
GTX102425 IP Image
GTX102425 IP Image

p63 antibody [N2C1], Internal

Research Use Only
GTX102425
GeneTex
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    p63 antibody [N2C1], Internal
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.34 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease. OBrien VP et al., 2016 Oct 31, Nat Microbiol
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  • A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Montoro DT et al., 2018 Aug, Nature
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  • Airway basal stem cells generate distinct subpopulations of PNECs. Mou H et al., 2021 Apr 20, Cell Rep
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  • Amplification and overexpression of TP63 and MYC as biomarkers for transition of cervical intraepithelial neoplasia to cervical cancer. Zhu D et al., 2014 May, Int J Gynecol Cancer
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  • Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression. Marsh T et al., 2020 Mar 9, Dev Cell
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  • Corneal Wound Healing Effects of Mesenchymal Stem Cell Secretome Delivered Within a Viscoelastic Gel Carrier. Fernandes-Cunha GM et al., 2019 May, Stem Cells Transl Med
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  • Cytological Immunostaining of HMGA2, LRP1B, and TP63 as Potential Biomarkers for Triaging Human Papillomavirus-Positive Women. Jiang Y et al., 2019 Jul, Transl Oncol
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  • Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. Kim DE et al., 2020 Mar, Aging Cell
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  • Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. Tata PR et al., 2018 Mar 26, Dev Cell
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  • Extracellular galectin-1 enhances adhesion to and invasion of oral epithelial cells by Porphyromonas gingivalis. Tamai R et al., 2018 Jul, Can J Microbiol
    Read more