GTX107562 WB Image
GTX107562 WB Image
p70 S6K antibody
GTX107562
Product group Antibodies
Overview
- SupplierGeneTex
- Product Namep70 S6K antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.37 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells. Liu YH et al., 2018 Jul 15, PhytomedicineRead more
- Bone morphogenetic protein 4 (BMP4) alleviates hepatic steatosis by increasing hepatic lipid turnover and inhibiting the mTORC1 signaling axis in hepatocytes. Peng Q et al., 2019 Dec 12, Aging (Albany NY)Read more
- Cadmium Activates Multiple Signaling Pathways That Coordinately Stimulate Akt Activity to Enhance c-Myc mRNA Stability. Tsai JS et al., 2016, PLoS OneRead more
- Inflammatory interferon activates HIF-1alpha-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathway. Yeh YH et al., 2018 Mar 27, J Exp Clin Cancer ResRead more
- Long non-coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes. Wang H et al., 2020 Jan, J Cell Mol MedRead more
- METTL3 serves an oncogenic role in human ovarian cancer cells partially via the AKT signaling pathway. Liang S et al., 2020 Apr, Oncol LettRead more
- miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1. Hwang-Verslues WW et al., 2011 May 26, OncogeneRead more
- RNA-seq reveals aurora kinase-driven mTOR pathway activation in patients with sarcomatoid metastatic renal cell carcinoma. Pal SK et al., 2015 Jan, Mol Cancer ResRead more
- The activation mechanism of plant S6 kinase (S6K), a substrate of TOR kinase, is different from that of mammalian S6K. Yaguchi M et al., 2020 Feb, FEBS LettRead more