Overview
- SupplierGeneTex
- Product NamePCAF antibody [C3], C-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionCBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress. Sengupta S et al., 2018 Jun - Jul, DNA Repair (Amst)Read more
- CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis. Cazzalini O et al., 2014 Jul, Nucleic Acids ResRead more
- USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy. Wang SA et al., 2020 Nov 30, Sci RepRead more