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GTX109666 WB Image
GTX109666 WB Image
GTX109666 WB Image

PCAF antibody [C3], C-term

Research Use Only
GTX109666
GeneTex
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    PCAF antibody [C3], C-term
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Isotype
    IgG
  • Scientific Description
    CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress. Sengupta S et al., 2018 Jun - Jul, DNA Repair (Amst)
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  • CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis. Cazzalini O et al., 2014 Jul, Nucleic Acids Res
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  • USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy. Wang SA et al., 2020 Nov 30, Sci Rep
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