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GTX104763 WB Image
GTX104763 WB Image
GTX104763 WB Image

PD-L1 antibody

Research Use Only
GTX104763
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
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Overview

  • Supplier
    GeneTex
  • Product Name
    PD-L1 antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.66 mg/ml
  • Isotype
    IgG
  • Scientific Description
    Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • A combination of anti-PD-L1 mAb plus Lm-LLO-E6 vaccine efficiently suppresses tumor growth and metastasis in HPV-infected cancers. Lin PL et al., 2017 Sep, Cancer Med
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  • An increase in BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non-small cell lung cancer via persistent activation of ERK signalling. Lin PL et al., 2017 Nov, Eur J Cancer
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  • Differential Expression and Clinicopathological Significance of HER2, Indoleamine 2,3-Dioxygenase and PD-L1 in Urothelial Carcinoma of the Bladder. Kim D et al., 2020 Apr 27, J Clin Med
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  • Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1. Li CW et al., 2018 Feb 12, Cancer Cell
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  • High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma. Lin YM et al., 2015, PLoS One
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  • IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. Chan LC et al., 2019 Jul 15, J Clin Invest
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  • Impact of FAK Expression on the Cytotoxic Effects of CIK Therapy in Triple-Negative Breast Cancer. Pan MR et al., 2019 Dec 30, Cancers (Basel)
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  • Intestine-Specific Homeobox Gene ISX Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression. Wang LT et al., 2017 Aug 1, Cancer Res
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  • Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Cha JH et al., 2018 Aug 16, Mol Cell
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  • NDAT Targets PI3K-Mediated PD-L1 Upregulation to Reduce Proliferation in Gefitinib-Resistant Colorectal Cancer. Huang TY et al., 2020 Aug 3, Cells
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