PERFORIN antibody, PAb
ORB67011
Overview
- SupplierBiorbyt
- Product NamePERFORIN antibody, PAb
- Delivery Days Customer16
- ApplicationsWestern Blot
- Applications SupplierWB:1:1000-1:5000 WB
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- HostRabbit
- IsotypeIgG
- Scientific DescriptionRabbit polyclonal to PERFORIN.PERFORIN (PRF1) is a cytolytic protein found in the granules of CD8 T-cells and NK cells. Upondegranulation, PERFORIN inserts itself into the target cells plasma membrane, forming a pore. Thelytic membrane-inserting part of PERFORIN is the MACPF domain, which shares homology withcholesterol-dependent cytolysins from Gram-positive bacteria. PERFORIN has structural andfunctional similarities to complement component 9 (C9). Like C9, PERFORIN creates transmembranetubules and is capable of lysing non-specifically a variety of target cells. PERFORIN is one of themain cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cellandnatural killer-cell-mediated cytolysis. Defects in PERFORIN cause familial hemophagocyticlymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood.
- ReactivityHuman, Mouse
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203