GTX110218 IHC-P Image
GTX110218 IHC-P Image
PLA2G4A antibody
GTX110218
Product group Antibodies
Overview
- SupplierGeneTex
- Product NamePLA2G4A antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.3 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- cPLA2alpha mediates TGF-beta-induced epithelial-mesenchymal transition in breast cancer through PI3k/Akt signaling. Chen L et al., 2017 Apr 6, Cell Death DisRead more
- Cysteinyl Leukotriene Synthesis via Phospholipase A2 Group IV Mediates Exercise-induced Bronchoconstriction and Airway Remodeling. Ueno H et al., 2020 Jul, Am J Respir Cell Mol BiolRead more
- Cytosolic phospholipase A2alpha modulates cell-matrix adhesion via the FAK/paxillin pathway in hepatocellular carcinoma. Guo P et al., 2019 May, Cancer Biol MedRead more