PLAUR antibody
ORB154129
Product group Antibodies
Overview
- SupplierBiorbyt
- Product NamePLAUR antibody
- Delivery Days Customer16
- Applications SupplierWB: 1:500-2000 WB
- CertificationResearch Use Only
- IsotypeIgG
- Scientific DescriptionRabbit polyclonal antibody to PLAUR. Urokinase plasminogen activator surface receptor (uPAR, also known as PLAUR or CD87) is a 4565 kDa, highly glycosylated, GPIanchored membrane protein. It contains three homologous domains (D1D3) of which the Nterminal one (D1) represents the uPAbinding domain. After binding to uPAR, urokinase plasminogen activator (uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis.
- Storage Instruction-20°C
- UNSPSC12352203