GTX104302 ICC/IF Image
GTX104302 ICC/IF Image
PLK1 antibody [N2C2], Internal
GTX104302
Product group Antibodies
Overview
- SupplierGeneTex
- Product NamePLK1 antibody [N2C2], Internal
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionSerine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Aerobic glycolysis supports hepatitis B virus protein synthesis through interaction between viral surface antigen and pyruvate kinase isoform M2. Wu YH et al., 2021 Mar, PLoS PathogRead more
- N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo. Liu LY et al., 2013 Nov 18, Chem Res ToxicolRead more
- SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Hwang G et al., 2017 May 1, DevelopmentRead more