PPM1A antibody

Catalog number: GTX109744_100ul
Brand: GeneTex
Packing: 100 ul
Other sizes: 25 ul
Price: € 334.00
Expected delivery time: 10 days
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GTX109744 WB Image
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Product specifications for - PPM1A antibody

Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoCytoChemistry; ImmunoFluorescence; ImmunoHistoChemistry; ImmunoHistoChemistry Parrafin; Western Blot
Species: Human, Mouse, Rat
Host: Rabbit
Target: PPM1A
Target description: protein phosphatase, Mg2+/Mn2+ dependent 1A
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Storage instructions: 2-¦C to 8-¦C, -20-¦C or -80-¦C
Scientific information: 
Scientific info: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]
Gene ID: 5494
Swiss prot ID: P35813
Additional information: 
Synonyms: PP2CA; PP2Calpha; PP2C-ALPHA; protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA
"PPM1A is a RelA phosphatase with tumor suppressor-like activity." Lu X et al., 2014 May 29, Oncogene Read more