GTX116016 WB Image
Presenilin 1 antibody [C1C2], Internal
GTX116016
Product group Antibodies
Overview
- SupplierGeneTex
- Product NamePresenilin 1 antibody [C1C2], Internal
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.53 mg/ml
- IsotypeIgG
- Scientific DescriptionAlzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203