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GTX113533 IHC-P Image
GTX113533 IHC-P Image
GTX113533 IHC-P Image

PSMB8 antibody [N2C3]

Research Use Only
GTX113533
GeneTex
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    PSMB8 antibody [N2C3]
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.38 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Activation of the Nrf2 signaling pathway and neuroprotection of nigral dopaminergic neurons by a novel synthetic compound KMS99220. Lee JA et al., 2018 Jan, Neurochem Int
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  • Downregulation of PA28alpha induces proteasome remodeling and results in resistance to proteasome inhibitors in multiple myeloma. Gu Y et al., 2020 Dec 14, Blood Cancer J
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