PSMD10 antibody [3F6] - Overexpression Validated

GeneTex

PSMD10 antibody [3F6] - Overexpression Validated

10

Flow Cytometry, Western Blot

Research Use Only

Monoclonal

3F6

1 mg/ml

Mouse

IgG

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and TP53/p53. Overexpression is leading to phosphorylation of RB1 and proteosomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to TP53/p53 and the mono- and polyubiquitination of TP53/p53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.

Human

2°C to 8°C,-20°C

12352203