PTEN antibody - KO/KD, Orthogonal Validated

Catalog number: GTX101025_100ul
Brand: GeneTex
Packing: 100 ul
Other sizes: 25 ul
Price: € 334.00
Expected delivery time: 10 days
Quantity:
GTX101025 ICC/IF Image
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GTX101025 IHC-P Image
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GTX101025 IHC-P Image
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GTX101025 IHC-P Image
GTX101025 IHC-P Image...
GTX101025 WB Image
GTX101025 IHC-P Image...
GTX101025 WB Image
GTX101025 WB Image...
GTX101025 WB Image
GTX101025 ICC/IF Image...
GTX101025 WB Image
GTX101025 IHC-P Image...
GTX101025 WB Image...
GTX101025 WB Image...

Product specifications for - PTEN antibody - KO/KD, Orthogonal Validated

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoCytoChemistry; ImmunoFluorescence; ImmunoHistoChemistry; ImmunoHistoChemistry Parrafin; Western Blot
Species: Human, Mouse, Porcine, Rat
Host: Rabbit
Target: PTEN
Target description: phosphatase and tensin homolog
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1.68 mg/ml
Storage instructions: 2-¦C to 8-¦C, -20-¦C or -80-¦C
Scientific information: 
Scientific info: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq]
Gene ID: 5728
Swiss prot ID: P60484
Additional information: 
Synonyms: 10q23del; BZS; CWS1; DEC; GLM2; MHAM; mitochondrial phosphatase and tensin protein alpha; mitochondrial PTENalpha; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; phosphatase and tensin-like protein; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase; PTEN1; PTENbeta; TEP1
"Efficient Generation of Somatic Cell Nuclear Transfer-Competent Porcine Cells with Mutated Alleles at Multiple Target Loci by Using CRISPR/Cas9 Combined with Targeted Toxin-Based Selection System." Sato M et al., 2017 Dec 4, Int J Mol Sci Read more
"HOXA10 is associated with temozolomide resistance through regulation of the homologous recombinant DNA repair pathway in glioblastoma cell lines." Kim JW et al., 2014 May, Genes Cancer Read more
"MicroRNA-200c Promotes Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating PTEN and FOG2 Expression." Mei S et al., 2015, PLoS One Read more
"miR-214 targets the PTEN-mediated PI3K/Akt signaling pathway and regulates cell proliferation and apoptosis in ovarian cancer." Liu J et al., 2017 Nov, Oncol Lett Read more
"Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathway." Qian L et al., 2018 Feb, Cytotechnology Read more
"Promotion of mitotic catastrophe via activation of PTEN by paclitaxel with supplement of mulberry water extract in bladder cancer cells." Chen NC et al., 2016 Feb 3, Sci Rep Read more
"Prostate tumorigenesis induced by PTEN deletion involves estrogen receptor beta repression." Mak P et al., 2015 Mar 31, Cell Rep Read more
"RNA-seq reveals aurora kinase-driven mTOR pathway activation in patients with sarcomatoid metastatic renal cell carcinoma." Pal SK et al., 2015 Jan, Mol Cancer Res Read more
"UBE2M-mediated p27(Kip1) degradation in gemcitabine cytotoxicity." Huang AM et al., 2011 Jul 1, Biochem Pharmacol Read more