GTX130418 WB Image
PTEN (phospho Thr366/Ser370) antibody
GTX130418
Product group Antibodies
Overview
- SupplierGeneTex
- Product NamePTEN (phospho Thr366/Ser370) antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration3.53 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- The Msp Protein of Treponema denticola Interrupts Activity of Phosphoinositide Processing in Neutrophils. Jones MM et al., 2019 Nov, Infect ImmunRead more