Bio-Connect
GTX104015 IP Image
GTX104015 IP Image
GTX104015 IP Image

Pyruvate Dehydrogenase E1 alpha antibody

Research Use Only
GTX104015
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    Pyruvate Dehydrogenase E1 alpha antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1.67 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1); dihydrolipoyl transacetylase (DLAT; MIM 608770) (E2; EC 2.3.1.12); and dihydrolipoyl dehydrogenase (DLD; MIM 238331) (E3; EC 1.8.1.4). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex (Brown et al., 1994 [PubMed 7853374]).[supplied by OMIM]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus Vulgaris. Chen Y et al., 2015 Sep 25, J Biol Chem
    Read more
  • Protein kinase B (PKB/AKT1) formed signaling complexes with mitochondrial proteins and prevented glycolytic energy dysfunction in cultured cardiomyocytes during ischemia-reperfusion injury. Deng W et al., 2014 May, Endocrinology
    Read more
  • Selective knockdown of hexokinase 2 in rods leads to age-related photoreceptor degeneration and retinal metabolic remodeling. Zhang R et al., 2020 Oct 20, Cell Death Dis
    Read more
  • Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. Chao LC et al., 2012 Dec, J Lipid Res
    Read more
  • Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy. Jonus HC et al., 2020 Jan, Biomed Pharmacother
    Read more