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ProductsBack/Rad50 antibody [13B3] - KO/KD, Orthogonal Validated
GTX70228 WB Image
GTX70228 WB Image
GTX70228 WB Image

Rad50 antibody [13B3] - KO/KD, Orthogonal Validated

Research Use Only
GTX70228
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
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Product group Antibodies
ReactivityHuman, Monkey, Mouse, Rat
Price on request
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More than 130 suppliers
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Overview

  • Supplier
    GeneTex
  • Product Name
    Rad50 antibody [13B3] - KO/KD, Orthogonal Validated
  • Delivery Days Customer
    10
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    13B3
  • Concentration
    2.24 mg/ml
  • Host
    Mouse
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]
  • Reactivity
    Human, Monkey, Mouse, Rat
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • 4beta-Hydroxywithanolide E selectively induces oxidative DNA damage for selective killing of oral cancer cells. Tang JY et al., 2018 Mar, Environ Toxicol
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  • 53BP1 promotes ATM activity through direct interactions with the MRN complex. Lee JH et al., 2010 Feb 3, EMBO J
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  • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Paull TT et al., 2000 Jul 27-Aug 10, Curr Biol
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  • A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation. van der Burg M et al., 2006 Jan, J Clin Invest
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  • A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. Zhu J et al., 2013 Mar, EMBO Mol Med
    Read more
  • A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. Bae NS et al., 2007 May 11, Mol Cell
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  • Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Bartkova J et al., 2008 Dec, Mol Oncol
    Read more
  • Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways. Collaco RF et al., 2009 Sep 15, Virology
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  • Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase. Schwartz RA et al., 2009 Jun, J Virol
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  • Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes. Fleisig HB et al., 2007 Jul 19, Oncogene
    Read more