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GTX118249 WB Image
GTX118249 WB Image
GTX118249 WB Image

Rad51 antibody

Research Use Only
GTX118249
GeneTex
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    Rad51 antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.63 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • NELF-E is recruited to DNA double-strand break sites to promote transcriptional repression and repair. Awwad SW et al., 2017 May, EMBO Rep
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  • Significance of cyclin D1 overexpression in progression and radio-resistance of pediatric ependymomas. Liang ML et al., 2018 Jan 5, Oncotarget
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  • Survivin contributes to DNA repair by homologous recombination in breast cancer cells. Vequaud E et al., 2016 Jan, Breast Cancer Res Treat
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