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GTX100469 ICC/IF Image
GTX100469 ICC/IF Image
GTX100469 ICC/IF Image

Rad51 antibody [N1C2]

Research Use Only
GTX100469
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    Rad51 antibody [N1C2]
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1.31 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • An SR protein is essential for activating DNA repair in malaria parasites. Goyal M et al., 2021 Aug 15, J Cell Sci
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  • BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance. Wang Y et al., 2019 Dec 11, Nat Commun
    Read more
  • BRCA1 Mutational Complementation Induces Synthetic Viability. Nacson J et al., 2020 Jun 4, Mol Cell
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  • BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Nacson J et al., 2018 Sep 25, Cell Rep
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  • BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Nacson J et al., 2018 Oct 30, Cell Rep
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  • BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Ge C et al., 2015 Mar 17, Proc Natl Acad Sci U S A
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  • Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes. Chakraborty A et al., 2016 Oct 5, Nat Commun
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  • CTRP3 Activates the AMPK/SIRT1-PGC-1alpha Pathway to Protect Mitochondrial Biogenesis and Functions in Cerebral Ischemic Stroke. Gao J et al., 2020 Dec, Neurochem Res
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  • Essential Role of BRCA2 in Ovarian Development and Function. Weinberg-Shukron A et al., 2018 Sep 13, N Engl J Med
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  • GRB2 enforces homology-directed repair initiation by MRE11. Ye Z et al., 2021 Aug, Sci Adv
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