Overview
- SupplierGeneTex
- Product NameRad51 antibody [N1C2]
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.31 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- An SR protein is essential for activating DNA repair in malaria parasites. Goyal M et al., 2021 Aug 15, J Cell SciRead more
- BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance. Wang Y et al., 2019 Dec 11, Nat CommunRead more
- BRCA1 Mutational Complementation Induces Synthetic Viability. Nacson J et al., 2020 Jun 4, Mol CellRead more
- BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Nacson J et al., 2018 Sep 25, Cell RepRead more
- BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Nacson J et al., 2018 Oct 30, Cell RepRead more
- BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Ge C et al., 2015 Mar 17, Proc Natl Acad Sci U S ARead more
- Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes. Chakraborty A et al., 2016 Oct 5, Nat CommunRead more
- CTRP3 Activates the AMPK/SIRT1-PGC-1alpha Pathway to Protect Mitochondrial Biogenesis and Functions in Cerebral Ischemic Stroke. Gao J et al., 2020 Dec, Neurochem ResRead more
- Essential Role of BRCA2 in Ovarian Development and Function. Weinberg-Shukron A et al., 2018 Sep 13, N Engl J MedRead more
- GRB2 enforces homology-directed repair initiation by MRE11. Ye Z et al., 2021 Aug, Sci AdvRead more