RELB antibody, PAb
ORB76316
ApplicationsWestern Blot
Product group Antibodies
ReactivityHamster, Human, Mouse, Rat
Overview
- SupplierBiorbyt
- Product NameRELB antibody, PAb
- Delivery Days Customer16
- ApplicationsWestern Blot
- Applications Supplier0.1-0.5 μg/ml WB
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration500 ug/ml
- HostRabbit
- IsotypeIgG
- Scientific DescriptionRabbit Polyclonal to RELB. RELB(v-rel reticuloendotheliosis viral oncogene homolog B) is also known as IREL. The International Radiation Hybrid Mapping Consortium assigned the RELB gene to chromosome 19. By RT-PCR and immunocytochemical analyses, Clark et al. (1999) showed that RELB expression correlated with dendritic cell activation.NF-kappa-B-inducing kinase is required for osteoclastogenesis in response to pathologic stimuli. Vaira et al. (2008) found that overexpression of Relb, but not Rela, rescued differentiation of mouse Nik/osteoclast precursors, indicating that blockade of the alternative NF-kappa-B pathway, rather than the classical NF-kappa-B pathway, is responsible for the osteoclastogenic defect in the absence of Nik. Using Relb/mice, they showed that Relb itself was required for Rankl-induced osteoclastogenesis in vitro and for TNF-induced bone resorption in vivo. Both Relb/and Nik/mice were resistant to tumor-mediated osteolysis. Vaira et al. (2008) concluded that the alternative NF-kappa-B pathway, via RELB, plays an essential and unique role in RANKL signaling toward osteoclast development.
- ReactivityHamster, Human, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203