Bio-Connect

RIP3 antibody [Rippy-3]

Research Use Only
GTX16090
GeneTex
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    RIP3 antibody [Rippy-3]
  • Delivery Days Customer
    10
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    Rippy-3
  • Host
    Mouse
  • Isotype
    IgG
  • Scientific Description
    Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Over expression of RIP3 induces apoptosis and NF-kB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203