RIT2 antibody

GeneTex

RIT2 antibody

10

Western Blot

Research Use Only

Polyclonal

~1 mg/ml

Rabbit

IgG

The Ras super-family comprises a group of structurally related low molecular weight (20-30 kDa) proteins, which bind GTP or GDP and exhibit a low intrinsic GTPase activity. They are involved in signal transduction and the regulation of a variety of cellular processes, including cell growth, transformation, differentiation and morphogenesis, nucleocytoplasmic transport, and apoptosis. Ras proteins promote cancer by disrupting the normal controls of cell proliferation and differentiation. All Ras subgroups (Ras, Rho, Rab, Ran, and ADP ribosylation factor) contain five highly conserved domains (G1-G5) and act as molecular switches by alternating between an active GTP-bound form and an inactive GDP-bound form. Rit2 (Ras-like protein in neurons) and Rit1 (Ras-like protein in tissues) share 50% homology to Ras. Both contain the five highly conserved domains (G1-G5), bind GTP in vitro, and are membrane-associated. However, both lack a CAAX box and their mechanism of membrane association is distinct from the typical Ras protein. Rit is a non-lipid-modified Ras-related protein, which lacks any known recognition signal for C-terminal lipidation. Rit1 and Rit2 share a unique effector domain (DPTIEDAYK) that is 100% conserved between murine and human proteins. Rit1 is expressed ubiquitously, but Rit2 is expressed only in subsets of neurons and may be involved in calcium-mediated signaling within neurons. Rit uses novel effector pathways to regulate proliferation and transformation. It has been suggested that Rit1 and Rit2 play important role in the regulation of signaling pathways, distinct from those controlled by Ras. Ras and associated pathways have also been implicated in the development and maintenance of themammalian retina.

Human

2°C to 8°C,-20°C

12352203