Overview
- SupplierGeneTex
- Product NameRPA32 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.64 mg/ml
- IsotypeIgG
- Scientific DescriptionRequired for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo. Parisotto M et al., 2018 Jun 4, J Exp MedRead more