SDHB antibody

Catalog number: GTX113833_100ul
Brand: GeneTex
Packing: 100 ul
Other sizes: 25 ul
Price: € 334.00
Expected delivery time: 10 days
Quantity:
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GTX113833 IHC-P Image
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GTX113833 IHC-P Image
GTX113833 IHC-P Image...
GTX113833 IHC-P Image
GTX113833 IHC-P Image...
GTX113833 IHC-P Image
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GTX113833 WB Image
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Product specifications for - SDHB antibody

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoCytoChemistry; ImmunoFluorescence; ImmunoHistoChemistry; ImmunoHistoChemistry Parrafin; Western Blot
Host: Rabbit
Target: SDHB
Target description: succinate dehydrogenase complex iron sulfur subunit B
Clonality: Polyclonal
Isotype: IgG
Controle: NCI-H929 , mouse brain
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1.49 mg/ml
Storage instructions: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Scientific information: 
Scientific info: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]
Gene ID: 6390
Swiss prot ID: P21912
Additional information: 
Synonyms: CWS2; IP; iron-sulfur subunit of complex II; PGL4; SDH; SDH1; SDH2; SDHIP; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
" mutations abrogate iron-sulfur cluster assembly leading to cavitating leukoencephalopathy." Ishiyama A et al., 2017 Oct, Neurol Genet Read more
"Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease." Siew JJ et al., 2019 Aug 2, Nat Commun Read more
"The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure." Lee H et al., 2017 Apr 28, J Biol Chem Read more
"Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the alpha-Ketoglutarate Signaling Pathway." Tseng CW et al., 2018 Jun 1, Cancer Res Read more