GTX113833 ICC/IF Image
GTX113833 ICC/IF Image
SDHB antibody
GTX113833
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameSDHB antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.49 mg/ml
- IsotypeIgG
- Scientific DescriptionComplex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- IBA57 mutations abrogate iron-sulfur cluster assembly leading to cavitating leukoencephalopathy. Ishiyama A et al., 2017 Oct, Neurol GenetRead more
- Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntingtons disease. Siew JJ et al., 2019 Aug 2, Nat CommunRead more
- The natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II. Min HY et al., 2019 Oct 24, Cell Death DisRead more
- The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure. Lee H et al., 2017 Apr 28, J Biol ChemRead more
- Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the alpha-Ketoglutarate Signaling Pathway. Tseng CW et al., 2018 Jun 1, Cancer ResRead more