SETD8 antibody

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Product specifications for - SETD8 antibody

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	ImmunoCytoChemistry; ImmunoFluorescence; ImmunoHistoChemistry; ImmunoHistoChemistry Parrafin; Western Blot
Species:	C. Elegans, Human
Host:	Rabbit
Target:	KMT5A
Target description:	lysine methyltransferase 5A
Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Controle:	U87-MG

Properties:
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Concentration:	1 mg/ml
Storage instructions:	2-¦C to 8-¦C, -20-¦C or -80-¦C

Scientific information:
Scientific info:	Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones.
Gene ID:	387893
Swiss prot ID:	Q9NQR1

Additional information:

Synonyms:

H4-K20-HMTase KMT5A; H4-K20-HMTase SETD8; H4-K20-specific histone methyltransferase; H4K20-specific histone methyltransferase splice variant Set8b; histone-lysine N-methyltransferase KMT5A; histone-lysine N-methyltransferase SETD8; lysine (K)-specific methyltransferase 5A; lysine N-methyltransferase 5A; lysine-specific methylase 5A; N-lysine methyltransferase KMT5A; N-lysine methyltransferase SETD8; PR/SET domain containing protein 8; PR/SET domain-containing protein 07; PR/SET07; PR-Set7; SET domain containing (lysine methyltransferase) 8; SET domain-containing protein 8; SET07; SET8; SETD8

"L3MBTL1 regulates ALS/FTD-associated proteotoxicity and quality control." Lu J et al., 2019 Jun, Nat Neurosci

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Product specifications for - SETD8 antibody