Overview
- SupplierGeneTex
- Product NameSETD8 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionHistone methyltransferase that specifically monomethylates Lys-20 of histone H4. H4 Lys-20 monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- L3MBTL1 regulates ALS/FTD-associated proteotoxicity and quality control. Lu J et al., 2019 Jun, Nat NeurosciRead more