SHANK2 Antibody (OASE00176)
OASE00176
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, Other Application
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetShank2
Overview
- SupplierAviva Systems Biology
- Product NameSHANK2 Antibody (OASE00176)
- Delivery Days Customer23
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDS23b-6
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID171093
- Target nameShank2
- Target descriptionSH3 and multiple ankyrin repeat domains 2
- Target synonymscortactin-binding protein 1; CortBP1; GKAP/SAPAP-interacting protein; proline-rich synapse-associated protein 1; ProSAP1; SH3 and multiple ankyrin repeat domains protein 2; SH3 and multiple ankyrin repeat domains protein 2-like; SH3/ankyrin domain gene 2; Spank-3
- HostMouse
- IsotypeIgG1
- Scientific DescriptionShank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimers disease (3).
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203