SHANK3 Antibody (OASE00184)
OASE00184
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, Other Application
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetShank3
Overview
- SupplierAviva Systems Biology
- Product NameSHANK3 Antibody (OASE00184)
- Delivery Days Customer23
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDS69-46
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID59312
- Target nameShank3
- Target descriptionSH3 and multiple ankyrin repeat domains 3
- Target synonymsproline-rich synapse-associated protein 2; Prosap2; SH3 and multiple ankyrin repeat domains protein 3; SH3/ankyrin domain gene 3; Shank postsynaptic density protein 3a; Spank-2
- HostMouse
- IsotypeIgG2b
- Scientific DescriptionShank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling; specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation (2). Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders (3).
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203