Overview
- SupplierGeneTex
- Product NameSMAD2 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.55 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A Fucoxanthinol Induces Apoptosis in a Pancreatic Intraepithelial Neoplasia Cell. Terasaki M et al., 2021 Mar-Apr, Cancer Genomics ProteomicsRead more
- Antroquinonol Targets FAK-Signaling Pathway Suppressed Cell Migration, Invasion, and Tumor Growth of C6 Glioma. Thiyagarajan V et al., 2015, PLoS OneRead more
- Blocking transforming growth factor-beta reduces the migration and invasion of the residual tumour after TAE. Song S et al., 2019, Am J Transl ResRead more
- Huangqi Shengmai Yin Protects against Radiation-Induced Cardiac Fibrosis Injury by Regulating the TGF-beta1/Smads and MMPs. Gu J et al., 2019, Evid Based Complement Alternat MedRead more
- Molecular dissection of the oncogenic role of ETS1 in the mesenchymal subtypes of head and neck squamous cell carcinoma. Gluck C et al., 2019 Jul, PLoS GenetRead more
- SREBP-1 is a novel mediator of TGFbeta1 signaling in mesangial cells. Chen G et al., 2014 Dec, J Mol Cell BiolRead more