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SOS1 antibody

Research Use Only
ORB154220
Biorbyt
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    Biorbyt
  • Product Name
    SOS1 antibody
  • Delivery Days Customer
    16
  • Applications Supplier
    WB: 1:500-2000 WB
  • Certification
    Research Use Only
  • Isotype
    IgG
  • Scientific Description
    Rabbit polyclonal antibody to SOS1. Son of sevenless (SOS) was first identified in Drosophila as a guanine nucleotide exchange factor (GEF) for Ras acting downstream of the Sevenless receptor (1). Two closely related homologs of Drosophila SOS are found in mammalian cells: SOS1 and SOS2 (2). SOS1 consists of histone folds, Dbl (DH) and pleckstrin (PH) homology domains, a Ras exchange motif (REM), and Cdc25 homology and polyproline domains (3). SOS1 binds to GRB2, NCK, and other adaptor proteins, and plays an important role in ERK activation downstream of protein tyrosine kinase receptor (RTK). Research studies have identified mutations in the corresponding SOS1 gene of patients with Noonan syndrome, a developmental disorder characterized by short stature, facial dysmorphia, and congenital heart defects
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203