Overview
- SupplierGeneTex
- Product NameSPOP antibody [N1C1]
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.1 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Mutational and expressional analyses of SPOP, a candidate tumor suppressor gene, in prostate, gastric and colorectal cancers. Kim MS et al., 2013 Jul, APMISRead more
- SPOP promotes FADD degradation and inhibits NF-kappaB activity in non-small cell lung cancer. Luo J et al., 2018 Sep 26, Biochem Biophys Res CommunRead more
- SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth. Luo J et al., 2017 Feb 5, Biochem Biophys Res CommunRead more