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GTX106942 WB Image
GTX106942 WB Image
GTX106942 WB Image

SPOP antibody [N1C1]

Research Use Only
GTX106942
GeneTex
Product group Antibodies
Price on request
Packing Size
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Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    SPOP antibody [N1C1]
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.1 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Mutational and expressional analyses of SPOP, a candidate tumor suppressor gene, in prostate, gastric and colorectal cancers. Kim MS et al., 2013 Jul, APMIS
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  • SPOP promotes FADD degradation and inhibits NF-kappaB activity in non-small cell lung cancer. Luo J et al., 2018 Sep 26, Biochem Biophys Res Commun
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  • SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth. Luo J et al., 2017 Feb 5, Biochem Biophys Res Commun
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