SPTBN2 Antibody / Spectrin beta III
ORB534451
Overview
- SupplierBiorbyt
- Product NameSPTBN2 Antibody / Spectrin beta III
- Delivery Days Customer16
- ApplicationsFlow Cytometry
- Applications SupplierWestern blot: 1-2ug/ml,Flow cytometry: 1-2ug/million cells in 0.1ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1) FACS, IHC-P, WB
- CertificationResearch Use Only
- Clone IDSCNB3-2R
- IsotypeIgG
- Scientific DescriptionSpectrins are principle components of a cells membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [RefSeq]
- UNSPSC12352203