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STAT3 antibody [C3], C-term - KO/KD, Comparison Validated
Catalog number:
GTX104616_25ul
Brand:
GeneTex
Packing:
25 ul
Other sizes:
100 ul
Price:
€ 172.00
Expected delivery time:
10 days
Quantity:
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General
Product specifications for - STAT3 antibody [C3], C-term - KO/KD, Comparison Validated
Overview:
Product group:
Antibodies
Category:
Primary Antibodies
Application:
ImmunoCytoChemistry; ImmunoFluorescence; Western Blot
Species:
Human, Mouse, Plant, Rat
Host:
Rabbit
Target:
STAT3
Target description:
signal transducer and activator of transcription 3
Clonality:
Polyclonal
Conjugation:
Unconjugated
Isotype:
IgG
Properties:
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352203
Concentration:
0.48 mg/ml
Storage instructions:
2-¦C to 8-¦C, -20-¦C or -80-¦C
Scientific information:
Scientific info:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]
Gene ID:
6774
Swiss prot ID:
P40763
Additional information:
Synonyms:
acute-phase response factor; ADMIO; ADMIO1; APRF; DNA-binding protein APRF; HIES; signal transducer and activator of transcription 3
